Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma

MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to MEK inhibition and changes in cellular metabolism. Using quantitative mass spectrometry-based metabolomics, we identified in preclinical models 21 plasma metabolites includ...

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Publicat a:Mol Cancer Ther
Autors principals: Ang, Joo Ern, Pal, Akos, Asad, Yasmin J, Henley, Alan T, Valenti, Melanie, Box, Gary, de haven Brandon, Alexis, Revell, Victoria L, Skene, Debra.J, Venturi, Miro, Rueger, Ruediger, Meresse, Valerie, Eccles, Suzanne A, de Bono, Johann S, Kaye, Stanley B, Workman, Paul, Banerji, Udai, Raynaud, Florence.I
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112418/
https://ncbi.nlm.nih.gov/pubmed/28637716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0881
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