Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma

MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to MEK inhibition and changes in cellular metabolism. Using quantitative mass spectrometry-based metabolomics, we identified in preclinical models 21 plasma metabolites includ...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Ang, Joo Ern, Pal, Akos, Asad, Yasmin J, Henley, Alan T, Valenti, Melanie, Box, Gary, de haven Brandon, Alexis, Revell, Victoria L, Skene, Debra.J, Venturi, Miro, Rueger, Ruediger, Meresse, Valerie, Eccles, Suzanne A, de Bono, Johann S, Kaye, Stanley B, Workman, Paul, Banerji, Udai, Raynaud, Florence.I
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112418/
https://ncbi.nlm.nih.gov/pubmed/28637716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0881
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