Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation

INTRODUCTION: To generate biomarkers of target engagement or predictive response for multi-target drugs is challenging. One such compound is the multi-AGC kinase inhibitor AT13148. Metabolic signatures of selective signal transduction inhibitors identified in preclinical models have previously been...

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Détails bibliographiques
Publié dans:Metabolomics
Auteurs principaux: Pal, Akos, Asad, Yasmin, Ruddle, Ruth, Henley, Alan T., Swales, Karen, Decordova, Shaun, Eccles, Suzanne A ., Collins, Ian, Garrett, Michelle D., De Bono, Johann, Banerji, Udai, Raynaud, Florence I.
Format: Artigo
Langue:Inglês
Publié: Springer US 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154022/
https://ncbi.nlm.nih.gov/pubmed/32285223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-020-01676-0
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