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Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

The APO-type proline-arginine-rich host defense peptides exhibit potent in vitro killing parameters against Enterobacteriaceae but not to other bacteria. Because of the excellent in vivo properties against systemic and local infections, attempts are regularly made to further improve the activity spe...

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Bibliografske podrobnosti
izdano v:Front Chem
Main Authors: Ostorhazi, Eszter, Hoffmann, Ralf, Herth, Nicole, Wade, John D., Kraus, Carl N., Otvos Jr., Laszlo
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111444/
https://ncbi.nlm.nih.gov/pubmed/30186829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00359
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