Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs

The designer proline-rich antimicrobial peptide (PrAMP) Chex1-Arg20 amide (ARV-1502) is active against Gram-negative and Gram-positive pathogens in different murine infection models when administered parenterally and possesses a wide therapeutic index. Here we studied the pharmacokinetics of ARV-150...

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書目詳細資料
發表在:Front Chem
Main Authors: Brakel, Alexandra, Volke, Daniela, Kraus, Carl N., Otvos, Laszlo, Hoffmann, Ralf
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863955/
https://ncbi.nlm.nih.gov/pubmed/31799234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00753
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