Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs

The designer proline-rich antimicrobial peptide (PrAMP) Chex1-Arg20 amide (ARV-1502) is active against Gram-negative and Gram-positive pathogens in different murine infection models when administered parenterally and possesses a wide therapeutic index. Here we studied the pharmacokinetics of ARV-150...

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Vydáno v:Front Chem
Hlavní autoři: Brakel, Alexandra, Volke, Daniela, Kraus, Carl N., Otvos, Laszlo, Hoffmann, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863955/
https://ncbi.nlm.nih.gov/pubmed/31799234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00753
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