Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

Constitutive NF-κB signaling represents a hallmark of chronic inflammation and autoimmune diseases. The E3 ligase TNF receptor–associated factor 6 (TRAF6) acts as a key regulator bridging innate immunity, pro-inflammatory cytokines, and antigen receptors to the canonical NF-κB pathway. Structural an...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Brenke, Jara K., Popowicz, Grzegorz M., Schorpp, Kenji, Rothenaigner, Ina, Roesner, Manfred, Meininger, Isabel, Kalinski, Cédric, Ringelstetter, Larissa, R'kyek, Omar, Jürjens, Gerrit, Vincendeau, Michelle, Plettenburg, Oliver, Sattler, Michael, Krappmann, Daniel, Hadian, Kamyar
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109917/
https://ncbi.nlm.nih.gov/pubmed/29950522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002649
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