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Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling. To elucidate the underlying molecular mechanisms, we investigated the effect of IFNγ and TNFα on the proliferation a...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Iguchi, Mayumi, Hiroi, Miki, Kanegae, Haruhide, Ohmori, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109523/
https://ncbi.nlm.nih.gov/pubmed/30158833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3979606
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