Downregulation of Bcl-2 sensitises interferon-resistant renal cancer cells to Fas

Interferon α (IFNα) is used to treat patients with advanced renal cell carcinoma (RCC) despite limited clinical benefit. IFNα can induce Fas receptor-mediated apoptosis by direct activation of pro-caspase-8 followed by activation of caspase-3. Alternative, indirect activation of caspase-3 via mitoch...

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Detalhes bibliográficos
Main Authors: Kelly, J D, Dai, J, Eschwege, P, Goldberg, J S, Duggan, B P, Williamson, K E, Bander, N H, Nanus, D M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364752/
https://ncbi.nlm.nih.gov/pubmed/15188008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601895
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