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Downregulation of Bcl-2 sensitises interferon-resistant renal cancer cells to Fas
Interferon α (IFNα) is used to treat patients with advanced renal cell carcinoma (RCC) despite limited clinical benefit. IFNα can induce Fas receptor-mediated apoptosis by direct activation of pro-caspase-8 followed by activation of caspase-3. Alternative, indirect activation of caspase-3 via mitoch...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364752/ https://ncbi.nlm.nih.gov/pubmed/15188008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601895 |
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