Inhibition of Bcl-2 family members sensitises soft tissue leiomyosarcomas to chemotherapy

BACKGROUND: Leiomyosarcoma is an aggressive soft tissue sarcoma with a 5-year survival rate of 15 to 60%. Treatment options for inoperable or metastatic patients are limited owing to frequent resistance of tumours to chemotherapy and radiation. In this study, we hypothesised that antiapoptotic Bcl-2...

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Опубликовано в: :Br J Cancer
Главные авторы: de Graaff, Marieke A, de Rooij, Marije A J, van den Akker, Brendy E W M, Gelderblom, Hans, Chibon, Fréderic, Coindre, Jean-Michel, Marino-Enriquez, Adrian, Fletcher, Jonathan A, Cleton-Jansen, Anne-Marie, Bovée, Judith V M G
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891502/
https://ncbi.nlm.nih.gov/pubmed/27140314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.117
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