The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approa...

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Pubblicato in:Nat Commun
Autori principali: Jakobsson, Magnus E., Małecki, Jędrzej M., Halabelian, Levon, Nilges, Benedikt S., Pinto, Rita, Kudithipudi, Srikanth, Munk, Stephanie, Davydova, Erna, Zuhairi, Fawzi R., Arrowsmith, Cheryl H., Jeltsch, Albert, Leidel, Sebastian A., Olsen, Jesper V., Falnes, Pål Ø.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109062/
https://ncbi.nlm.nih.gov/pubmed/30143613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05646-y
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