The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approa...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Jakobsson, Magnus E., Małecki, Jędrzej M., Halabelian, Levon, Nilges, Benedikt S., Pinto, Rita, Kudithipudi, Srikanth, Munk, Stephanie, Davydova, Erna, Zuhairi, Fawzi R., Arrowsmith, Cheryl H., Jeltsch, Albert, Leidel, Sebastian A., Olsen, Jesper V., Falnes, Pål Ø.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109062/
https://ncbi.nlm.nih.gov/pubmed/30143613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05646-y
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