The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)

Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many non-histone proteins, including eukaryotic elongation factor 1 alpha (eEF1A). However, the functional significance of eEF1A methylation remains obsc...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Małecki, Jędrzej, Aileni, Vinay Kumar, Ho, Angela Y.Y., Schwarz, Juliane, Moen, Anders, Sørensen, Vigdis, Nilges, Benedikt S., Jakobsson, Magnus E., Leidel, Sebastian A., Falnes, Pål Ø.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416902/
https://ncbi.nlm.nih.gov/pubmed/28108655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx002
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