Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury

Hesperidin has been reported to attenuate myocardial ischemia/reperfusion (I/R) injury; however, its effect on autophagy during myocardial I/R and the underlying mechanism remains unknown. The present study aimed to investigate whether hesperidin inhibited I/R-induced excessive myocardial autophagy...

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Опубликовано в: :Int J Mol Med
Главные авторы: Li, Xuefei, Hu, Xiaorong, Wang, Jichun, Xu, Weipan, Yi, Chunfeng, Ma, Ruisong, Jiang, Hong
Формат: Artigo
Язык:Inglês
Опубликовано: D.A. Spandidos 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108872/
https://ncbi.nlm.nih.gov/pubmed/30066841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3794
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