bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway

Autophagy is involved in the development and/or progression of many diseases, including myocardial ischemia/reperfusion (I/R). In this study, we hypothesized a protective role of basic fibroblast growth factor (bFGF) both in vivo and in vitro and demonstrated that excessive autophagy and ubiquitinat...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Wang, Zhou-Guang, Wang, Yue, Huang, Yan, Lu, Qin, Zheng, Lei, Hu, Dong, Feng, Wen-Ke, Liu, Yan-Long, Ji, Kang-Ting, Zhang, Hong-Yu, Fu, Xiao-Bing, Li, Xiao-Kun, Chu, Mao-Ping, Xiao, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365411/
https://ncbi.nlm.nih.gov/pubmed/25787015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09287
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