Sevoflurane Postconditioning Protects Rat Hearts against Ischemia-Reperfusion Injury via the Activation of PI3K/AKT/mTOR Signaling

Phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway plays a key role in myocardial ischemia-reperfusion (I/R) injury. Mammalian target of rapamycin (mTOR), a downstream target of PI3K/AKT signaling, is necessary and sufficient to protect the heart from I/R injury. Inhaled anesthetic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Jing, Wang, Chen, Yu, Shuchun, Luo, Zhenzhong, Chen, Yong, Liu, Qin, Hua, Fuzhou, Xu, Guohai, Yu, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255182/
https://ncbi.nlm.nih.gov/pubmed/25471136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07317
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