Melatonin Inhibits mTOR-Dependent Autophagy during Liver Ischemia/Reperfusion

Background: Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive oxygen species produced during ischemia/reperfusion (I/R). Melatonin (MLT) is a potent and endogenous anti-oxidant that has beneficial effects in liver I/R injury. In this st...

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Bibliografiske detaljer
Main Authors: Jung-Woo Kang, Hong-Ik Cho, Sun-Mee Lee
Format: Artigo
Sprog:Inglês
Udgivet: Cell Physiol Biochem Press GmbH & Co KG 2014-01-01
Serier:Cellular Physiology and Biochemistry
Fag:
Autophagy
Mammalian target of rapamycin
Melatonin
Oxidative stress
Calpain
Ischemia/reperfusion
Online adgang:http://www.karger.com/Article/FullText/356647
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