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Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity
A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally ex...
में बचाया:
मुख्य लेखकों: | , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
The National Academy of Sciences
2001
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC61084/ https://ncbi.nlm.nih.gov/pubmed/11698657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241339498 |
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