Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity
A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally ex...
Spremljeno u:
| Izdano u: | Proc Natl Acad Sci U S A |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2001
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698657/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241339498 |
| Oznake: |
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|