Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity
A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally ex...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698657/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241339498 |
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