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Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity

A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally ex...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Persson, Egon, Kjalke, Marianne, Olsen, Ole H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61084/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241339498
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