Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients

A prospective multicenter study was conducted to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of fludarabine plasma (f-ara-a) and intracellular triphosphate (f-ara-ATP) in children undergoing hematopoietic cell transplantation (HCT) and receiving fludarabine with conditioning. Pl...

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Udgivet i:Biol Blood Marrow Transplant
Main Authors: Ivaturi, Vijay, Dvorak, Christopher C., Chan, Danna, Liu, Tao, Cowan, Morton J., Wahlstrom, Justin, Stricherz, Melisa, Jennissen, Cathryn, Orchard, Paul J., Tolar, Jakub, Pai, Sung-Yun, Huang, Liusheng, Aweeka, Francesca, Long-Boyle, Janel
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108324/
https://ncbi.nlm.nih.gov/pubmed/28684371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2017.06.021
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