Determination of melphalan in human plasma by UPLC-UV method

It is desirable to develop a fast method for quantification of melphalan due to its instability. Here we report a method for quantification of melphalan (MPL) in human plasma using a UPLC-PDA system. Briefly, 50 µL plasma sample was mixed with 25 µL internal standard (2500 ng/mL acetylmelphalan in m...

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Veröffentlicht in:Cancer Chemother Pharmacol
Hauptverfasser: Huang, Liusheng, Cheah, Vincent, Chan, Danna, Marzan, Florence, Dvorak, Christopher C., Aweeka, Francesca T, Long-Boyle, Janel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6490959/
https://ncbi.nlm.nih.gov/pubmed/30847504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03786-6
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