Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

Recent advances in single-cell technologies have permitted the investigation of heterogeneous cell populations at previously unattainable resolution. Here we apply such approaches to resolve the molecular mechanisms driving disease in mouse hematopoietic stem cells (HSCs), using JAK2V617F mutant mye...

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Udgivet i:Blood
Main Authors: Shepherd, Mairi S., Li, Juan, Wilson, Nicola K., Oedekoven, Caroline A., Li, Jiangbing, Belmonte, Miriam, Fink, Juergen, Prick, Janine C. M., Pask, Dean C., Hamilton, Tina L., Loeffler, Dirk, Rao, Anjana, Schröder, Timm, Göttgens, Berthold, Green, Anthony R., Kent, David G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107881/
https://ncbi.nlm.nih.gov/pubmed/29991556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-821066
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