Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion

Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation o...

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Detalhes bibliográficos
Main Authors: Kent, David G., Li, Juan, Tanna, Hinal, Fink, Juergen, Kirschner, Kristina, Pask, Dean C., Silber, Yvonne, Hamilton, Tina L., Sneade, Rachel, Simons, Benjamin D., Green, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672217/
https://ncbi.nlm.nih.gov/pubmed/23750118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001576
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