Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat

Adeno-associated virus (AAV) is the only known eukaryotic virus capable of targeted integration in human cells. An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the viral terminal repeats required for AAV DNA replication are located on chromosome (ch) 19. Both ch-19 R...

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Bibliographic Details
Main Authors: Young, Samuel M., Samulski, Richard Jude
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC61074/
https://ncbi.nlm.nih.gov/pubmed/11707592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241508998
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