Evidence for Packaging of rep-cap Sequences into Adeno-Associated Virus (AAV) Type 2 Capsids in the Absence of Inverted Terminal Repeats: a Model for Generation of rep-Positive AAV Particles

We previously reported that a 350-bp region of the adeno-associated virus (AAV) type 2 rep gene contains a cis-acting element responsible for the Rep-dependent replication of a transiently transfected rep-cap plasmid. In this study, we further report that replicated rep-cap sequences can be packaged...

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Detalhes bibliográficos
Main Authors: Nony, Pascale, Chadeuf, Gilliane, Tessier, Jacques, Moullier, Philippe, Salvetti, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140600/
https://ncbi.nlm.nih.gov/pubmed/12477885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.776-781.2003
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