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Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat

Adeno-associated virus (AAV) is the only known eukaryotic virus capable of targeted integration in human cells. An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the viral terminal repeats required for AAV DNA replication are located on chromosome (ch) 19. Both ch-19 R...

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Hlavní autoři: Young, Samuel M., Samulski, Richard Jude
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC61074/
https://ncbi.nlm.nih.gov/pubmed/11707592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241508998
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