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Relative Evolutionary Rates in Proteins Are Largely Insensitive to the Substitution Model

The relative evolutionary rates at individual sites in proteins are informative measures of conservation or adaptation. Often used as evolutionarily aware conservation scores, relative rates reveal key functional or strongly selected residues. Estimating rates in a phylogenetic context requires spec...

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Bibliographic Details
Published in:Mol Biol Evol
Main Authors: Spielman, Stephanie J, Kosakovsky Pond, Sergei L
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107055/
https://ncbi.nlm.nih.gov/pubmed/29924340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy127
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