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Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability

It is standard practice to model site-to-site variability of substitution rates by discretizing a continuous distribution into a small number, K, of equiprobable rate categories. We demonstrate that the variance of this discretized distribution has an upper bound determined solely by the choice of K...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mannino, Frank, Wisotsky, Sadie, Kosakovsky Pond, Sergei L., Muse, Spencer V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051046/
https://ncbi.nlm.nih.gov/pubmed/32119689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229493
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