Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with β-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions

Enterococcus faecium isolates that harbor LiaFSR substitutions but are phenotypically susceptible to daptomycin (DAP) by current breakpoints are problematic, since predisposition to resistance may lead to therapeutic failure. Using a simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodyn...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kebriaei, Razieh, Rice, Seth A., Singh, Kavindra V., Stamper, Kyle C., Dinh, An Q., Rios, Rafael, Diaz, Lorena, Murray, Barbara E., Munita, Jose M., Tran, Truc T., Arias, Cesar A., Rybak, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105850/
https://ncbi.nlm.nih.gov/pubmed/29760141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00315-18
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