Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

Macroautophagy/autophagy failure with the accumulation of autophagosomes is an early neuropathological feature of Alzheimer disease (AD) that directly affects amyloid beta (Aβ) metabolism. Although loss of presenilin 1 function has been reported to impair lysosomal function and prevent autophagy flu...

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Publicat a:Autophagy
Autors principals: Barbero-Camps, Elisabet, Roca-Agujetas, Vicente, Bartolessis, Isabel, de Dios, Cristina, Fernández-Checa, Jose C., Marí, Montserrat, Morales, Albert, Hartmann, Tobias, Colell, Anna
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper–Basic Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103708/
https://ncbi.nlm.nih.gov/pubmed/29862881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1438807
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