Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

Macroautophagy/autophagy failure with the accumulation of autophagosomes is an early neuropathological feature of Alzheimer disease (AD) that directly affects amyloid beta (Aβ) metabolism. Although loss of presenilin 1 function has been reported to impair lysosomal function and prevent autophagy flu...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Barbero-Camps, Elisabet, Roca-Agujetas, Vicente, Bartolessis, Isabel, de Dios, Cristina, Fernández-Checa, Jose C., Marí, Montserrat, Morales, Albert, Hartmann, Tobias, Colell, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper–Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103708/
https://ncbi.nlm.nih.gov/pubmed/29862881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1438807
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados