Nuclear TP53: An unraveled function as transcriptional repressor of PINK1

The tumor suppressor TP53/p53 is a key protein in both neurodegenerative diseases and cancer. Thus, TP53-linked cell death appears exacerbated in several age-related neuropathologies, while TP53 mutation-associated phenotypes indicate a loss of function accounting for approximately half of cancers....

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Bibliographic Details
Published in:Autophagy
Main Authors: Checler, Frédéric, Goiran, Thomas, Alves da Costa, Cristine
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
Subjects:
Autophagic Punctum
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103405/
https://ncbi.nlm.nih.gov/pubmed/29749796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1450022
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