Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

Autophagic and mitophagic defects are consistently observed in Alzheimer's disease-affected brains. However, the mechanistic defects underlying these anatomical lesions remained unexplained. We have delineated a molecular cascade by which PSEN1 and PSEN2 (presenilins 1 and 2) control PINK1 tran...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Autophagy
Egile Nagusiak: Checler, Frédéric, Goiran, Thomas, Alves da Costa, Cristine
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2017
Gaiak:
Autophagic Punctum
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788489/
https://ncbi.nlm.nih.gov/pubmed/28914586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1363950
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