Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion

AIMS/HYPOTHESIS: Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage, and may regulate glucagon secretion from alpha cells. ZnT8 is a zinc efflux transporter highly expressed in beta cells and polymorphisms in the ZnT8 (slc30a8) gene in man are associated wit...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Diabetologia
Main Authors: Wijesekara, N., Dai, F.F., Hardy, A.B., Giglou, P. R., Bhattacharjee, A., Koshkin, V., Chimienti, F., Gaisano, H.Y., Rutter, G.A., Wheeler, M.B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101216/
https://ncbi.nlm.nih.gov/pubmed/20424817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1733-9
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares