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Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion
AIMS/HYPOTHESIS: Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage, and may regulate glucagon secretion from alpha cells. ZnT8 is a zinc efflux transporter highly expressed in beta cells and polymorphisms in the ZnT8 (slc30a8) gene in man are associated wit...
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| Опубликовано в: : | Diabetologia |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6101216/ https://ncbi.nlm.nih.gov/pubmed/20424817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1733-9 |
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