Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion

AIMS/HYPOTHESIS: Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage, and may regulate glucagon secretion from alpha cells. ZnT8 is a zinc efflux transporter highly expressed in beta cells and polymorphisms in the ZnT8 (slc30a8) gene in man are associated wit...

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發表在:Diabetologia
Main Authors: Wijesekara, N., Dai, F.F., Hardy, A.B., Giglou, P. R., Bhattacharjee, A., Koshkin, V., Chimienti, F., Gaisano, H.Y., Rutter, G.A., Wheeler, M.B.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101216/
https://ncbi.nlm.nih.gov/pubmed/20424817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1733-9
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