A rare mutation in ABCC8/SUR1 leading to altered K(ATP) channel activity and β-cell glucose sensing is associated with type 2 diabetes mellitus in adults

OBJECTIVE: ATP-sensitive K(+) (K(ATP)) channels link glucose metabolism to the electrical activity of the pancreatic β-cell to regulate insulin secretion. Mutations in either the Kir6.2 or SUR1 subunit of the channel have previously been shown to cause neonatal diabetes. We describe here an activati...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Tarasov, Andrei I., Nicolson, Tamara, Riveline, Jean-Pierre, Taneja, Tarvinder K., Baldwin, Stephen A., Baldwin, Jocelyn M., Charpentier, Guillaume, Gautier, Jean-François, Froguel, Philippe, Vaxillaire, Martine, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101196/
https://ncbi.nlm.nih.gov/pubmed/18346985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1547
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