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Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells

Pancreatic β cells respond to increases in glucose concentration with enhanced metabolism, the closure of ATP-sensitive K(+) channels and electrical spiking. The latter results in oscillatory Ca(2+) influx through voltage-gated Ca(2+) channels and the activation of insulin release. The relationship...

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Bibliografske podrobnosti
Main Authors: Tarasov, Andrei I., Semplici, Francesca, Li, Daliang, Rizzuto, Rosario, Ravier, Magalie A., Gilon, Patrick, Rutter, Guy A.
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631125/
https://ncbi.nlm.nih.gov/pubmed/23149488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1177-9
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