The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca(2+) influx. As well as activating ATP-consuming processes, cytosolic Ca(2+) increases may also potentiate mitochondrial ATP synthesis. Until recently, the ability to study the role of...

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Detalhes bibliográficos
Main Authors: Tarasov, Andrei I., Semplici, Francesca, Ravier, Magalie A., Bellomo, Elisa A., Pullen, Timothy J., Gilon, Patrick, Sekler, Israel, Rizzuto, Rosario, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400633/
https://ncbi.nlm.nih.gov/pubmed/22829870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039722
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