The pore-forming subunit MCU of the mitochondrial Ca(2+) uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

AIMS/HYPOTHESIS: Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca(2+) uptake into pancreatic beta cell mitochondria potentiates or antagonises this process is still a matter of debate. Although the mitochondrial Ca(2+) importer (MCU) complex is...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286857/
https://ncbi.nlm.nih.gov/pubmed/32350566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05148-x
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