Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical oxidative-stress defense mechanism through TRPA1, a neuronal redox-sensing Ca(2+)-influx channel. In TRPA1-enriched breast and lung...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100788/
https://ncbi.nlm.nih.gov/pubmed/29805077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.001
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