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Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

Several lines of evidence suggest that components of the tumor microenvironment, specifically basement membrane and extracellular matrix proteins, influence drug sensitivities. We previously reported differential drug sensitivity of tumor cells localized adjacent to laminin-rich extracellular matrix...

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Bibliografski detalji
Izdano u:NPJ Breast Cancer
Glavni autori: Zoeller, Jason J., Bronson, Roderick T., Selfors, Laura M., Mills, Gordon B., Brugge, Joan S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460247/
https://ncbi.nlm.nih.gov/pubmed/28649658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-017-0020-z
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