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Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

Several lines of evidence suggest that components of the tumor microenvironment, specifically basement membrane and extracellular matrix proteins, influence drug sensitivities. We previously reported differential drug sensitivity of tumor cells localized adjacent to laminin-rich extracellular matrix...

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Опубликовано в: :NPJ Breast Cancer
Главные авторы: Zoeller, Jason J., Bronson, Roderick T., Selfors, Laura M., Mills, Gordon B., Brugge, Joan S.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460247/
https://ncbi.nlm.nih.gov/pubmed/28649658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-017-0020-z
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