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Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein
The intrinsically disordered protein β-synuclein is known to inhibit the aggregation of its intrinsically disordered homologue, α-synuclein, which is implicated in Parkinson’s disease. While β-synuclein itself does not form fibrils at the cytoplasmic pH 7.4, alteration of pH and other environmental...
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| Veröffentlicht in: | J Mol Biol |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6100766/ https://ncbi.nlm.nih.gov/pubmed/29782835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.05.024 |
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