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Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity

Alpha-synuclein (αS) fibrils are toxic to cells and contribute to the pathogenesis and progression of Parkinson’s disease and other synucleinopathies. β-Synuclein (βS), which co-localizes with αS, has been shown to provide a neuroprotective effect, but the molecular mechanism by which this occurs re...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Yang, Xue, Williams, Jonathan K., Yan, Run, Mouradian, M. Maral, Baum, Jean
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879756/
https://ncbi.nlm.nih.gov/pubmed/31772376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54063-8
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