Apoptosis Signal Regulating Kinase 1 Deletion Mitigates α-Synuclein Pre-formed Fibril Propagation in Mice

α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease (PD) and Dementia with Lewy Bodies. Accumulating evidence from studies of postmortem human brains, rodent models and cultured neurons show that misfolded fibrillar α-Syn is transmitted from cell-to-cel...

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Bibliografiset tiedot
Julkaisussa:Neurobiol Aging
Päätekijät: Zhang, Jie, Park, Eun S., Park, Hye-Jin, Yan, Run, Grudniewska, Magda, Zhang, Xiaopei, Oh, Stephanie, Yang, Xue, Baum, Jean, Mouradian, M. Maral
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064162/
https://ncbi.nlm.nih.gov/pubmed/31734439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.09.012
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