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A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues
α-Synuclein (αS) is the primary protein associated with Parkinson's disease, and it undergoes aggregation from its intrinsically disordered monomeric form to a cross-β fibrillar form. The closely related homolog β-synuclein (βS) is essentially fibril-resistant under cytoplasmic physiological co...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5625065/ https://ncbi.nlm.nih.gov/pubmed/28710275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780528 |
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