Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α

IMPORTANCE: Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with manifold consequences for mammalian pathophysiology, including cardiovascular disease. A deeper understanding of TNF-α biology may enhance treatment precision. OBJECTIVE: To conduct an epigenome-wide analysis of blood-der...

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Veröffentlicht in:JAMA Cardiol
Hauptverfasser: Aslibekyan, Stella, Agha, Golareh, Colicino, Elena, Do, Anh N., Lahti, Jari, Ligthart, Symen, Marioni, Riccardo E., Marzi, Carola, Mendelson, Michael M., Tanaka, Toshiko, Wielscher, Matthias, Absher, Devin M., Ferrucci, Luigi, Franco, Oscar H., Gieger, Christian, Grallert, Harald, Hernandez, Dena, Huan, Tianxiao, Iurato, Stella, Joehanes, Roby, Just, Allan C., Kunze, Sonja, Lin, Honghuang, Liu, Chunyu, Meigs, James B., van Meurs, Joyce B. J., Moore, Ann Zenobia, Peters, Annette, Prokisch, Holger, Räikkönen, Katri, Rathmann, Wolfgang, Roden, Michael, Schramm, Katharina, Schwartz, Joel D., Starr, John M., Uitterlinden, André G., Vokonas, Pantel, Waldenberger, Melanie, Yao, Chen, Zhi, Degui, Baccarelli, Andrea A., Bandinelli, Stefania, Deary, Ian J., Dehghan, Abbas, Eriksson, Johan, Herder, Christian, Jarvelin, Marjo-Riitta, Levy, Daniel, Arnett, Donna K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2018
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Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100733/
https://ncbi.nlm.nih.gov/pubmed/29617535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2018.0510
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