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Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog (PTEN)/Phosphoinositide 3-Kinase (PI3K) Signaling Pathway

BACKGROUND: Atrial remodeling especially in the form of fibrosis is the most important substrate of atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on chronic intermittent hypoxia (CIH)-induced atrial remodeling and the pathophysiological mechanisms unde...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Med Sci Monit
Prif Awduron: Zhang, Kai, Zhao, Linru, Ma, Zuowang, Wang, Weiding, Li, Xiongfeng, Zhang, Yue, Yuan, Meng, Liang, Xue, Li, Guangping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Scientific Literature, Inc. 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100459/
https://ncbi.nlm.nih.gov/pubmed/30098136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.909800
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